ANtIMYcoBActeRIAL ActIVItY oF 4- AND 3,4-sUBstItUteD coUMARINs
نویسندگان
چکیده
The present article describes the evaluation of the in vitro activity against M. tuberculosis H37Rv of eight coumarin-derived aminoalcohols and amidoamines. Seven of the compounds display activity between 10 and 20 times higher than the classicall anti-TB drug ethambutol. The combination of coumarin scaffold with aminoalcohol fragments gave the most promising activities with MICs up to 0.32 μM.
منابع مشابه
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